Tumors were staged using the postoperative TNM classification. The immunoexpression levels of the proteins were assessed in lung tissue samples, using an enzyme‑linked immunosorbent assay. PATIENTS AND METHODS The study included 71 patients diagnosed with non- small-cell lung cancer (NSCLC). OBJECTIVES The aim of the study was to analyze the immunoexpression levels of 3 STAT proteins: STAT3, STAT5, and STAT6 in their phosphorylated forms (pSTATs), STAT inhibitors PIAS3 and SOCS3, and additionally cyclooxygenase 2 (COX‑2), as potential diagnostic and prognostic markers in lung cancer. On 30 July 2015, Ludmila Dvořáková died in a fire at her home in Prague.INTRODUCTION Signal transducer and activator of transcription (STAT) proteins are critically involved in tumorigenesis in various cancers, including lung cancer. In 2012 she was awarded the Antonin Dvořák Prize, presented by the Academy of Performing Arts in Prague, Music and Dance Faculty (HAMU) in recognition of individuals who promote and popularise Czech music. She was Gutrune on the Karl Böhm recording of Götterdämmerung in 1967.ĭvořáková was awarded the National Prize of the German Democratic Republic in 1972. 1982), a pupil of Václav Talich, whom she met in Ostrava and with whom she recorded an LP of Wagner operatic excerpts. ĭvořáková was married to conductor Rudolf Vašata (d. ĭvořáková sang at prominent opera houses throughout the world, including the Met.

Between 19 she sang at Bayreuth, appearing as Gutrune, Venus, Kundry, Ortrud and Brünnhilde, the latter role also being sung the following year under Solti at Covent Garden, with whom she also sang Isolde, a role she later sang under Colin Davis. Beginning in 1960 she was the dramatic soprano at the Berlin State Opera, and also performed in London, New York, Munich and Paris. In the early 1950s Dvořáková was engaged in Vienna, and sang Elisabeth in Don Carlos and the Kostelnicka in Jenůfa under Mackerras in East Berlin she was heard as Octavian in Der Rosenkavalier. Her operatic debut was in the title role of Katya Kabanova in Ostrava in 1949. Biography ĭvořáková studied at the Prague Conservatory. Ludmila Dvořáková (11 July 1923 in Kolín – 30 July 2015 in Prague) was a Czech operatic soprano.

Dozorcovia by Lukáš Kordiak